Am having a bit of challenge in laying out my form using sizers in wxPython, i would appreciate if someone would give me head start in laying out my form as shown in the image.

Please share the sources.
Thanks
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I would not mess with sizers manually when designing a complex gui. Just, please, use wxglade and customize manually afterwards.
It took 15 minutes to do this, mistakes included (I did not filled the list control, sorry):
This is the process I followed:
And finally, customize labels, sizer and widget names, etc.
Save the wxGlade file for future changes and produce the Python file (In the top Application dialog).
Trick: Do not modify the generated file, instead import and subclass your Frame in another file to code its functionality.
One last note: In my experience there are some differences in Linux and Windows with sizers and backgrounds. In Linux, do not use the default Frame’s BoxSizer as indicated in step 3. Instead add an wx.Panel on it, add a BoxSizer to the Panel and continue building from this sizer.