Currently I am running Apache and MySQL and I hear about people talking about GZipping content, something about ETags, using a CDN, adding expire headers, minifying text documents, combining script files, etc. I downloaded a Firefox add-on called YSlow and I noticed that many websites do not employ all of these tactics. I believe even Google has a D rating. So I ask, SO, how important are these optimizations?
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They depend highly on your traffic and resources at your disposal.
If you make the website for Joe’s Pizza in the middle of nowhere, there is no real need to waste time optimising the site, it will likely have a handful of visits a day.
But Stack Overflow receives thousands of hits a minute (probably more), so they use a CDN, distant expiry headers, minification, etc.