Each serial device shows up twice in /dev, once as a tty.* and once as a cu.*.
What is the cu.* device? How does it differ from the tty.* device?
ls -l /dev/*.usbmodem621
Output:
crw-rw-rw- 1 root wheel 11, 5 Dec 25 18:00 /dev/cu.usbmodem621
crw-rw-rw- 1 root wheel 11, 4 Dec 25 18:00 /dev/tty.usbmodem621
https://web.archive.org/web/20120602152224/http://lists.berlios.de/pipermail/gpsd-dev/2005-April/001288.html :