Question

Example:

System.out.println("in!");
AlertDialog.Builder dialog = new AlertDialog.Builder(this);
    dialog.setMessage("test!!!");
    dialog.setPositiveButton(R.string.dialog_ok, 
        new OnClickListener() {
            public void onClick(DialogInterface dialog, int which) {
                System.out.println("Only one click!");
            }
    });
    dialog.show();

Out:
in!
in!
Only one click!
Only one click!
Only one click!
Only one click!

Answer 1

Get the button (positive) and set enabled to false.

System.out.println("in!");
AlertDialog.Builder dialog = new AlertDialog.Builder(this);
dialog.setMessage("test!!!");
dialog.setPositiveButton(R.string.dialog_ok, 
    new OnClickListener() {
        public void onClick(DialogInterface dialog, int which) {
            // disable on 1st click;
            final AlertDialog alertDialog = (AlertDialog)dialog;
            alertDialog.getButton(DialogInterface.BUTTON_POSITIVE).setEnabled(false);
            System.out.println("Only one click!");
        }
});
dialog.show();