Features needed:
- A framework, allowing me to build tab-based application with custom design (like in Hotot twitter client), keeping the native os window frame.
- Compatible with Python.
- My application will be running under Win/OsX/Linux/.
- No Flash/Flex/AIR.
I also would like to ask if PySide does meet my requirements and is it worse or better than wxPython and Tkinter mentioned already?
I am the author of Hotot.
according to your requirements, the key for you to choose a framework is the UI framework should be able to access webview conveniently.
Hotot has several wrappers for different platforms. On Linux, we have both Qt and GTK version, on Windows, we provide a Qt version, on Mac, we have a Cocoa version, and of course we have a Chrome version. In a word, all they can easily access webkit.
PS: XULRunner is another good choice for native appearance.