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Home/ Questions/Q 6572583
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Editorial Team
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Editorial Team
Asked: May 25, 20262026-05-25T15:01:31+00:00 2026-05-25T15:01:31+00:00

I am afraid to see the error Could not load file or assembly ‘Interop.hMailServer’

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I am afraid to see the error Could not load file or assembly 'Interop.hMailServer' or one of its dependencies. Access is denied. while running a web application. The problem is I am running 32 bit web application in 64bit. Well, Visual Studio allows to change the built option to 32/64 but I just have web project with the source files to recompile by Google hours together I found this http://dailydotnettips.com/2011/07/03/could-not-load-file-or-assembly-presentationcore-or-one-of-its-dependencies-an-attempt-was-made-to-load-a-program-with-an-incorrect-format-a-solution/ hope it helps me. But I am working on windows 2003 server. Can anybody please tell me how to convert the application to run in 64 bit?

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  1. Editorial Team
    Editorial Team
    2026-05-25T15:01:31+00:00Added an answer on May 25, 2026 at 3:01 pm

    Have had to run this on numerous x64 ’03 machines to support older components.

    Run x86 bit applications on x64 – Documentation

    Start – Run – Navigate to :

    %systemdrive%\Inetpub\AdminScripts

    Run this statement:

    cscript.exe adsutil.vbs set W3SVC/AppPools/Enable32BitAppOnWin64 1

    EDIT 2 I hope this helps.

    I went through some of my old documents and found this syntax I used succesfully before:

    cscript %SYSTEMDRIVE%\inetpub\adminscripts\adsutil.vbs SET W3SVC/AppPools/Enable32bitAppOnWin64 1

    Also, remember to register IIS when it completes (in your .NET folder run)

    EDIT 3

    Start – Run – Enter the following:

    %SYSTEMROOT%\Microsoft.NET\Framework\v2.0.50727\aspnet_regiis.exe -i

    Without harping on – allow the .aspx extension in IIS afterwards as well.

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