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Home/ Questions/Q 6648499
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Editorial Team
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Editorial Team
Asked: May 26, 20262026-05-26T00:39:44+00:00 2026-05-26T00:39:44+00:00

I am getting Mailbox unavailable. The server response was: 5.4.1 Unable to relay for

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I am getting “Mailbox unavailable. The server response was: 5.4.1 Unable to relay for myemail@mydomain.com” when I try to send the mail using C# code.

Then I tested my smtp server here.

Here when I enter my smtp server, sender and recipient name. I got followoing message:

MAIL FROM: mymail@mydomain.com

SMTP -> FROM SERVER:

250 2.1.0 Sender OK

RCPT TO: anothermail@mydomain.com

SMTP -> FROM SERVER:

550 5.4.1 Relay Access Denied

SMTP -> ERROR: RCPT not accepted from server: 550 5.4.1 Relay Access
Denied

Message sending failed.

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  1. Editorial Team
    Editorial Team
    2026-05-26T00:39:45+00:00Added an answer on May 26, 2026 at 12:39 am

    That’s a config issue in the mail servier. It doesn’t allow you (your IP, your sender address) to send mail to the recipient.

    A properly configured mail server is extremely restrictive with relaying, to prevent it from being abused by spammers to send mails.

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