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I found Seed, which is basically a JavaScript environment and binding for programming GTK+. Are there any limitations compared to using e.g. C and C++? Are there any major speed concerns?
There won’t be any “major speed concerns”, and in general you shouldn’t find it to be much slower than C or C++ if you are writing good JS code.
Most of your overhead will be in the database / filesystem on a typical application. If you plan on doing complex computations, you may see a difference.
In short: it depends on what you are doing with it, but in general I wouldn’t say that you will see major speed concerns. It has worked well for me.
If you think it could be done in Python, JS will work just fine.