I get the following dialog when I try to load any DB project in Visual Studio.

There is nothing else locking it, nor are the permissions on that specific folder restrictive.
This used to work, but I re-installed VS2008, then Sp1, a few hot fixes and GDR2.
Now, when I try to load any DB project, I get the dialog above.
When I open VS, I get the following dialog; it’s different, but message is the same..

You can check locks on files by using process explorer:
http://windowsxp.mvps.org/processlock.htm
You can download process explorer here:
http://technet.microsoft.com/en-us/sysinternals/bb896653