Question

I recently came across this syntax, I am unaware of the difference.

I would appreciate it if someone could tell me the difference.

Answer 1

The answer is explained here.

To quote:

A class is free to implement
comparison any way it chooses, and it
can choose to make comparison against
None mean something (which actually
makes sense; if someone told you to
implement the None object from
scratch, how else would you get it to
compare True against itself?).

Practically-speaking, there is not much difference since custom comparison operators are rare. But you should use is None as a general rule.