I want to remove Help button from data validation.
In excel 2003 data validation this button is not there but now I want to remove this from excel 2007 data validation error.
Please don’t ask why you want to remove help button.
my project type is excel template of visual studio 2008.

EDIT
Is there any other way to accomplish this thing apart from Worksheet_Change? I think it might decrease performance.
You can’t remove the Help button if you are using the built in Data Validation. You would be well advised to simply live with the help button as the only known work-around will be time consuming to recreate Excel’s built-in functionality.
You’ll need to make a custom msgbox that listens for the Worksheet Change and checks the value. Here’s a VBA example basically taken from here: