Question

I wonder if typedef and #define are the same in C. What are the differences between them?

Answer 1

No.

#define is a preprocessor token: the compiler itself will never see it.
typedef is a compiler token: the preprocessor does not care about it.

You can use one or the other to achieve the same effect, but it’s better to use the proper one for your needs

#define MY_TYPE int
typedef int My_Type;

When things get “hairy”, using the proper tool makes it right

#define FX_TYPE void (*)(int)
typedef void (*stdfx)(int);

void fx_typ(stdfx fx); /* ok */
void fx_def(FX_TYPE fx); /* error */