I’m running across a problem with the rendering in WPF when I use Effects (specifically, a DropShadowEffect). This is what my UI is supposed to look like:

But when I start resizing the window, it will glitch at certain points and turn to this:

You can see the text is distorted and there is a darkish line on the right side of the Start Server button. The problem goes away if I remove the Effects. It this simply a bug in WPF or is there a way to fix it?
As Halley said, you might “suffer” from subpixel positioning. If you compile your application against .Net 4 FrameWork, you can set the UseLayoutRounding property of your window to switch this behaviour off.
If this doesn’t do the trick, try Software-Rendering to check back whether DX is giving you trouble (although I bet you won’t have to go there).