I’m trying to do a layout that looks like this:

Both the top and bottom parts have a defined height, however I want the two left/right sections in the middle to take up all available vertical space. Here’s what I got so far.
I made the middle sections an exact 500px just as a showcase, but as you can see, I also messed up the middle right section, and the bottom right section.
Are you talking about something like this:
Fullscreen (source linked below)
http://jsfiddle.net/xTh5f/4/