I’m using Django registration inside my project on a development server.
When I register a new user, I use EMAIL_BACKEND = ‘django.core.mail.backends.filebased.EmailBackend’ to get the activation link.
When I try to put the activation link into the web browser, I have an error, and the account is not activated.
It is said : 
Thank you.
This function is used to generate the key.
def create_profile(self, user):
"""
Create a ``RegistrationProfile`` for a given
``User``, and return the ``RegistrationProfile``.
The activation key for the ``RegistrationProfile`` will be a
SHA1 hash, generated from a combination of the ``User``'s
username and a random salt.
"""
salt = hashlib.sha1(str(random.random())).hexdigest()[:5]
username = user.username
if isinstance(username, unicode):
username = username.encode('utf-8')
activation_key = hashlib.sha1(salt+username).hexdigest()
return self.create(user=user,
activation_key=activation_key)
I received that mail. But I use EMAIL_BACKEND’django.core.mail.backends.filebased.EmailBackend’.
I think the problem comes from here. But I can’t test in production server.

I solved the problem actually It’s because I generate the email to send inside a file thanks to the file email backends provided by django for development purpose. Inside this file, when there is a carriage return, it adds an = characters. And this is the case with the link to active the account.
You shouldn’t have a
=character in your activation key.Although
sergzach‘s answer will work, I’d be more interested in finding out why that=is there in the first place.django-registrationusually generates the key as follows:Where are you generating yours?