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Home/ Questions/Q 6848179
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Editorial Team
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Editorial Team
Asked: May 27, 20262026-05-27T00:50:11+00:00 2026-05-27T00:50:11+00:00

I’m using Fedora 15 64bit and python 2.7 When I run python test.py from

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I’m using Fedora 15 64bit and python 2.7

When I run python test.py from command line it works well
but when I run subprocess.call(["python","test.py"]) from another python module I get

  File "/usr/lib64/python2.7/site.py", line 557, in <module>
    main()
  File "/usr/lib64/python2.7/site.py", line 539, in main
    known_paths = addusersitepackages(known_paths)
  File "/usr/lib64/python2.7/site.py", line 268, in addusersitepackages
    user_site = getusersitepackages()
  File "/usr/lib64/python2.7/site.py", line 243, in getusersitepackages
    user_base = getuserbase() # this will also set USER_BASE
  File "/usr/lib64/python2.7/site.py", line 233, in getuserbase
    USER_BASE = get_config_var('userbase')
  File "/usr/lib64/python2.7/sysconfig.py", line 535, in get_config_var
    return get_config_vars().get(name)
  File "/usr/lib64/python2.7/sysconfig.py", line 434, in get_config_vars
    _init_posix(_CONFIG_VARS)
  File "/usr/lib64/python2.7/sysconfig.py", line 287, in _init_posix
    raise IOError(msg)
IOError: invalid Python installation: unable to open /usr/local/lib64/python2.7/config/Makefile (No such file or directory)

How can I fix it?

UPDATE: This stack trace I get when run script from Eclipse.

  • when I run test.py from CL – it works
  • when I run script containing
    subprocess.call(["python","test.py"]) from CL – it also works
  • when I run script containing subprocess.call(["python","test.py"])
    from Eclipse – it fails
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1 Answer

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  1. Editorial Team
    Editorial Team
    2026-05-27T00:50:11+00:00Added an answer on May 27, 2026 at 12:50 am

    I assume you’re using something like pydev for development.

    If you have a look at the “Interpreter” tab in the “Run Configurations”, you should see the python path (with the “See resulting command-line…”) and the binary used for the command. Pydev alters the PYTHONPATH (it’s not the same as you have in the command line).

    I’d suggest you should try having a look inside (or even try to run the command line with the same PYTHONPATH as in pydev and see if you get the same errors.

    HTH

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