import os
os.system("notepad macros.txt")
or
from subprocess import Popen
Popen(["notepad", "macros.txt"])
both start notepad in the background. How to start it in the foreground?
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You can try to use the start command, maybe the /MAX option will force notepad to be in foreground, otherwise if you can wait untill notepad shutdown, use the /WAIT option/