Is <area> still the best way to handle irregular navigation menus, or is there a better way?
My navigation menu looks like this:

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You can use standard navigation markup:
and then do a 2D CSS transform (skew the element around the Y axis):
See this fiddle for a live example. See this for browser support info.
How to write the IE filter
Convert -10 degrees to radian by typing this in google:
You will get:
Then plug the value in M21.
Why would you use this method
navelement which is used by screen readers to figure out where the navigation is.