Question

Is it possible to use F5 OneConnect with non-http traffic? It seems like it might be possible to create iRules that can figure out when to attach/detach, but I haven’t seen any examples.

Answer 1

Yes, its possible.
As per F5 AskF5 SOL7208:

The OneConnect profile may be used with any TCP protocol, 
but will function only when applied to virtual servers that 
are processing simple request/response protocols where 
transaction boundaries are explicitly obvious, such as those 
in which each request and each response is contained within 
a single packet. 

So it would still depend on the protocol that you want to load-balance. What protocol are you going to load balance?