I’ve removed header, footer and borders from RadDataForm:
<t:RadDataForm ItemsSource="{Binding Item}" MinHeight="300" MinWidth="300"
AutoEdit="True" BorderThickness="0" Background="Transparent"
CommandButtonsVisibility="None" BorderBrush="Transparent"
ValidationSummaryVisibility="Collapsed" />
But two lines still present. How to remove horizontal lines?

Have you ever tried to style a control by using Blend?
Note that I use Silverlight, but it should be the same.
However put this property into you RadDataForm control:
Now it should look like this:
Now you have to set a style resource. You can put the style resource into app.xaml or in the same page of the control.
For example I have an
sdk:Page. For embed the Style in the same page of the control you have to do this:Alternatively you can try to use the theming property provided by Telerik:
this property allow you to don’t style the control, but it changes the appearance of all your control, and it is possible that you don’t like this theme.