Redmond has a good idea occasionally:
The next-gen Windows will come with a new programming foundation, letting developers build native apps with the same techniques they use for Web applications. Microsoft calls this new variety “tailored apps.”
There is always a steep learning curve for developing GUIs; each new toolkit you learn is different enough that it takes a lot of time and effort and frustration. Thus developing in HTML with CSS begins to look very appealing: it’s much easier and much more portable; and with HTML 5 and CSS 3, it is very powerful.
Is there any support yet on Ubuntu (or even better, a cross-platform toolkit) for developing native applications that use HTML/CSS for the GUI? To minimize overhead, I do not want to start a full browser session. (That’s not very good desktop integration.) I am particularly interested in answers for native JavaScript or Python 3, but any language would be alright (easier to learn a new language than a new GUI toolkit, in my book).
Edit: I have found this page, but have not had time to read it all or test it. It linked to Python XULRunner, but again I have no previous knowledge of it.
This was asked on Ask Ubuntu back in August of 2011.
In summary, the options are:
SeedKit
The JavaScript bindings for GNOME.
There are more options, but those are the two “big ones”.