Running X11/GTK programs on mac is quite a pain for me. It looks ugly, and it from time to time acts in weird ways. So I’m wondering what would be the natural choice to port a GTK program to Mac using native GUI frameworks like Cocoa. And by the way, is there any existing effort to manage such portings in a unified repository?
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Many parts of the GTK+ are already ported to OS X, see the home page of the GTK+ – OS X. So, in theory, you only have to re-compile your favorite GTK+ app on OS X with the Quartz back end to have it run natively. You mileage of course will vary.