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So I have an application that has a special file type .rxml associated to it.
If the application is already running and I open one of these files, it opens a new instance of the application. Is there a way to make the file open in the same application instance?
Yes, roughly-speaking, a new instance of the application will be launched, detect the existing instance and pass information to it, e.g. the path to the new file to be opened. You have a few options for this task, including WCF and Remoting.