There is a one system that required to implement which has number of large users and number of queries for second.
What will be the best approach creating tables on a multiple databases or in a single database ? and Why?.
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I would recommend one database with multiple instances. You can set up Master / Slave replication between those database instances.
Some useful links:
http://dev.mysql.com/doc/refman/5.0/en/replication.html
http://members.cox.net/midian/howto/mysqlReplication.htm