We are making a web service call on some data updates to sync another database. This web service call takes up some response time. Would adding it in a thread help at all? Any downfalls of doing this? If the web service calls fails, it fails and that is it. It is like a fire and forget call.
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You could use an Asynchronous Web Service call using asyncronous callbacks to prevent blocking of your main thread.
From MSDN: Making Asynchronous Web Service Calls