when i open a aspx page that have master page the visual studio crashed. no erorr or any thing only show Not Responding in title bar of visual studio . no problem when i in markup but crashed when i go in designer . only pages that have master page is crashed .visual studio 2010 ultimate.
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Hope this will help you to find cause of issue.
http://connect.microsoft.com/VisualStudio/feedback/details/534902/visual-studio-2010-crashes-when-editing-a-master-page-or-aspx-code-behind