When the mouse hovers on the modeline, a few lines of help appear (depending on the context).
How do I disable this help? I would like to do so because (at least for Emacs 23 on OS X Lion), the help does not go away if I switch to another program without moving the mouse.
If you mean a tooltip by “a few lines of help”, you can let help strings be displayed in the echo area rather than a pop-up window:
or
In case that you want Emacs not to display help strings at all, you can set the
show-help-functionvariable tonil:C-hf
tooltip-modeC-hv
tooltip-use-echo-area32.19.4 Properties with Special Meanings, GNU Emacs Lisp Reference Manual