
there’s a table and some ddl in updatepanel.
like this:

why this happens???
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I think that you forget to reset your drop down list and you place them again and again data.
So two thinks you can do. Use the IsPostBack for populate your dropdownlist and not populate them again if there is a post back, or on every post back, first clear the dropdown items them add again the list.
For fast check if the dropdownlist is the case, set
enableviewstate="false"on them