Until recently we were using Inno Setup for our installations, something I would like to continue doing, unless we can get an uninstall option in the start menu (thanks Giovanni Galbo), however we now need to GAC some external libraries, something I suspect is only doable (or at least only supported) though the .NET Setup Project.
Is it possible to call a GAC’ing library from another setup application?
According to http://jrsoftware.org/files/is5-whatsnew.htm you should be able to do it with v5.3 and above