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What is preferable?
dataGrid1.ItemsSource = data;
Or:
public MainWindow()
....
this.DataContext = data;
....
<DataGrid ItemsSource="{Binding}
In my opinion that depends on the design you are using.
If you’re using the MVVM pattern there’s no doubt about it: You’ll always use your ViewModel as the DataContext of your View.
In cases where you just want to bind a list to a ItemsSource without using MVVM I would prefer your first case.