Question

When calling a loop being performed in a C shared-library (dynamic library), Python will not receive a KeyboardInterrupt, and nothing will respond (or handle) CTRL+C.

What do I do?

Answer 1

Unless you use PyDLL or PYFUNCTYPE; the GIL is released during the ctypes calls. Therefore the Python interpreter should handle SIGINT by raising KeyboardInterrupt in the main thread if the C code doesn’t install its own signal handler.

To allow the Python code to run in the main thread; you could put the ctypes call into a background thread:

import threading

t = threading.Thread(target=ctypes_call, args=[arg1, arg2, ...])
t.daemon = True
t.start()
while t.is_alive(): # wait for the thread to exit
    t.join(.1)